As far as the US is concerned, sacrificing the UK for the sake of European stability is a good bet. America is quite happy to drain the UK's national wealth into the imploding Eurozone, to use our armed forces to provide the backbone to a Euro army, give up our independence to lessen the chances of the US having to intervene in Europe ever again, militarily or otherwise. And of course New York has long coveted London's status as the international financial centre. France wants all of this too, plus the UK's counter-balancing effect on German dominance. The Germans want our money; without the UK, the task of financing the continent would fall disproportionally on Germany, placing her at an international competitive disadvantage.
So before Cameron has even delivered his keynote speech, the international arm-twisting is already building up. You can be sure of one thing and one thing only, though; none of the 'advice' we will receive, and ever more forcefully receive as we move toward making a decision, will be based on Britain's own interests. We can therefore safely disregard as misleading all the arguments against a new European relationship as made from beyond the shores of these isles.
And of course will come the veiled threats and leaks, that the US will not share the most sensitive intelligence or defence secrets with the UK (she doesn't anyway), that the international corporations will desert our shores (not if we maintain the tax advantages and open access to European markets), our trade position will worsen (in fact it's more likely to improve with the freedom to negotiate new bilateral trade agreements), that we will lose our place in the world (or lead the Commonwealth to global pre-eminence). And of course the EU will use their billion pound budgets to distort public opinion. Against all of this we must stand steadfast, never deflected from making an epochal decision on the basis of one factor alone - British self-interest.